Section outline

  • General

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    Support of Establishment, Development and Mobility of Quality Research Teams at the Charles University CZ.1.07/2.3.00/30.0061

    ENDOTHELIAL PROGENITOR CELLS

    The electronic course provides information on endothelium and endothelial progenitor cells. Knowledge of this topic is required for gaining the credit in „Stem Cells and Regenerative Medicine“.

  • • ENDOTHELIAL PROGENITOR CELLS

    The electronic course covers the following topics:

    • Characterization of endothelial cells and their markers.
    • Origin of endothelial cells. Hemangioblast.
    • Isolation of endothelial progenitor cells.
    • In vitro differentiation of endothelial cells.
    • Vascularization: vasculogenesis, angiogenesis, arteriogenesis.
    • Nestin: marker of activated endothelial cells.
    • Therapeutic usage of endothelial progenitor cells.

  • CONCLUSION

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    References:

    Klika, E. et al. Embryologie, Avicenum, Praha, 1986, 384 s.

    Lendahl, U. et al. CNS stem cells express a new class of intermediate filament protein. Cell 1990, 60, 585–595.

    Masuda, H., Asahara, T. Postnatal endothelial progenitor cells for neovascularisation in tissue regeneration.Cardiovasc. Res. 2003, 58, 390-398.

    Mokrý, J. et al. Nestin expression by newly formed human blood vessels. Stem Cells Dev. 2004, 13, 658-664.

    Mokrý, J., Němeček, S. Angiogenesis of extra- and intraembryonic blood vessels is associated with expression of nestin in endothelial cells. Folia Biol (Prague) 1998, 44, 155-161.

    Mokrý, J., Němeček, S. Cerebral angiogenesis shows nestin expression in endothelial cells. Gen Physiol Biophys 1999, 18, 25-29.

    Yamashita, J. et al. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature 2000, 408 (6808), 92-96.

    Zovein, A.C. et al. Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell 2008, 3,625-636.